{"id":2447,"date":"2023-02-23T12:52:55","date_gmt":"2023-02-23T11:52:55","guid":{"rendered":"https:\/\/www.beachemie.com\/?post_type=maerkte&#038;p=2447"},"modified":"2026-07-17T12:08:12","modified_gmt":"2026-07-17T10:08:12","slug":"pharma-zwischenprodukte","status":"publish","type":"maerkte","link":"https:\/\/beachemie.com\/en\/maerkte\/pharma\/pharma-zwischenprodukte\/","title":{"rendered":"Chemical Pharma Intermediates"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"2447\" class=\"elementor elementor-2447\" data-elementor-post-type=\"maerkte\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f09558d e-flex e-con-boxed e-con e-parent\" data-id=\"3f09558d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-27feed32 e-con-full e-flex e-con e-child\" data-id=\"27feed32\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4191105f elementor-widget elementor-widget-text-editor\" data-id=\"4191105f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>In the synthesis of active pharmaceutical ingredients (APIs), acetates operate at the intersection of mild bases, phase-transfer agents, and coordination chemistry modifiers.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72fba938 elementor-widget elementor-widget-heading\" data-id=\"72fba938\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Acid scavenger in API synthesis<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3970684 elementor-widget elementor-widget-text-editor\" data-id=\"3970684\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>During condensation, coupling, or halogenation reactions in API synthesis, hydrochloric or hydrobromic acid is frequently generated as a by-product.<\/p><p>Anhydrous sodium acetate acts as an effective, non-nucleophilic acid scavenger.<\/p><p>It neutralizes the mineral acid to form acetic acid, preventing the degradation of acid-sensitive intermediates without triggering the unwanted side reactions that stronger inorganic bases, such as sodium hydroxide or carbonates, might cause.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a939446 elementor-widget elementor-widget-heading\" data-id=\"5a939446\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Catalysis and cross-coupling reactions<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-770646a1 elementor-widget elementor-widget-text-editor\" data-id=\"770646a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Acetate salts are key components in transition-metal-catalyzed cross-coupling reactions (e.g. Suzuki, Heck, or Buchwald\u2013Hartwig amination). Sodium acetate and potassium acetate frequently serve as bases that facilitate the transmetalation step.<\/p><p>In addition, metal acetates, such as palladium, zinc, and manganese acetates, are used directly as catalyst precursors because the acetate ligand readily exchanges with organic phosphine ligands in situ. <em>in situ <\/em>leicht mit organischen Phosphinliganden ausgetauscht wird.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"featured_media":3311,"parent":2443,"menu_order":10,"template":"","produkte":[],"class_list":["post-2447","maerkte","type-maerkte","status-publish","has-post-thumbnail","hentry","wpbf-post"],"acf":[],"_links":{"self":[{"href":"https:\/\/beachemie.com\/en\/wp-json\/wp\/v2\/maerkte\/2447"}],"collection":[{"href":"https:\/\/beachemie.com\/en\/wp-json\/wp\/v2\/maerkte"}],"about":[{"href":"https:\/\/beachemie.com\/en\/wp-json\/wp\/v2\/types\/maerkte"}],"version-history":[{"count":0,"href":"https:\/\/beachemie.com\/en\/wp-json\/wp\/v2\/maerkte\/2447\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/beachemie.com\/en\/wp-json\/wp\/v2\/maerkte\/2443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/beachemie.com\/en\/wp-json\/wp\/v2\/media\/3311"}],"wp:attachment":[{"href":"https:\/\/beachemie.com\/en\/wp-json\/wp\/v2\/media?parent=2447"}],"wp:term":[{"taxonomy":"produkte","embeddable":true,"href":"https:\/\/beachemie.com\/en\/wp-json\/wp\/v2\/produkte?post=2447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}